北京荣志海达生物科技有限公司
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025-86978335
所在地区：北京/海淀区
品牌名称：
型号规格：
产品标签：羰基蛋白质
产品卖点：新产品
销售渠道：医院
025-86978335
| 器械类别 | 二类医疗器械 | 科室 | 诊断相关科室 |
| 功能 | 检测试剂盒 | 标准目录 | 体外循环及血液处理设备 |
| 耗材类别 | 其他分类 | 进口 | |
| 家用与否 |
产品介绍：
【产品名称】
通用名称：阿狄科®羰基蛋白质检测试剂盒（酶联免疫法）（生物样本）
英文名称：Carbonylated Proteins
【包装规格】
96人份/盒
【预期用途】
用于测定生物样品中的蛋白质结合羰基化合物，例如 EDTA 血浆、支气管肺泡灌洗液和脑脊液、细胞提取物和其他可溶性蛋白质样品。仅供科研使用。
【背景知识】
活性氧 (ROS) 可以氧化细胞中的蛋白质、脂质和 DNA，从而在结构和功能上破坏它们。蛋白质被自由基氧化，以各种方式修饰或降解其氨基酸。蛋白质接受新的官能团，如羰基或羟基，可导致蛋白质断裂、交联形成、三级结构破坏和功能丧失。活性氧还与动脉粥样硬化、阿尔茨海默氏症、帕金森氏症和类风湿性关节炎等疾病直接相关以及衰老过程和致癌作用。
蛋白质结合羰基化合物由多种氧化机制形成，是氧化损伤的敏感标志物。蛋白质结合羰基化合物的含量可以通过用DNPH衍生化并随后测定结合的抗 DNPH 抗体来确定。 ELISA 方法能够以微克范围内的蛋白质含量进行定量羰基测定。
适应症：
动脉硬化
阿尔茨海默氏症
帕金森氏症
类风湿关节炎
尿毒症
糖尿病
衰老过程
致癌
参考文献：
1. Beal, M. F. Oxidatively modified proteins in aging and disease.Free radical biology& medicine 32,797-803(2002).
2. Berlett,B. S.& Stadtman, E.R.Protein oxidation in aging, disease, and oxidative stress.The Journal of biological chemistry 272,20313-6 (1997).
3. Buss, H., Chan,T. P., Sluis,K. B., Domigan,N. M.& Winterbourn, C.C. Protein carbo-nyl measurement by a sensitive ELISA method.Free radical biology & medicine 23,361-6 (1997).
4. Cao, G.& Cutler,R.G.Protein oxidation and aging.I. Difficulties in measuring re-active protein carbonyls in tissues using 2,4-dinitrophenylhydrazine.Archives ofbiochemistry and biophysics 320,106-14(1995).
5. Davies, K. J.,Delsignore,M.E.& Lin, S. W. Protein damage and degradation by oxygen radicals.ll.Modification of amino acids. TheJournal of biological chemistry262,9902-7(1987).
6. Dean,R.T., Fu, S., Stocker,R.& Davies,M.J.Biochemistry and pathology of radical-mediated protein oxidation.The Biochemical journal324 ( Pt 1,1-18(1997).
7. Descamps-Latscha，B.& Witko-Sarsat,V. lmportance of oxidatively modified proteins in chronic renal failure.Kidney international. Supplement 78,S108-13(2001).
8. Galli, F. Protein damage and inflammation in uraemia and dialysis patients. Ne-phrology, dialysis, transplantation : official publication of the European Dialysis andTransplant Association-European Renal Association 22 Suppl 5, v20-36 (2007).
9. Gladstone,L. M.& Levine, R.L. Oxidation of proteins in neonatal lungs. Pediatrics93,764-8 (1994).
10.Lenz, a G.et al. Oxidatively modified proteins in bronchoalveolar lavage fluid of patients with ARDS and patients at-risk for ARDS.The European respiratory journal13,169-74 (1999).
11.Levine,R.L.Carbonyl modified proteins in cellular regulation, aging, and disease.Free radical biology & medicine 32,790-6(2002).
12.Levine,R.L.& Stadtman,E.R. Oxidative modification of proteins during aging.Experimental gerontology 36,1495-502 (2001).
13.Marnett,L. J.， Riggins，J. N. & West,J. D. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.The Journalof clinical investigation 111,583-93(2003).
14.Matzi, V.et al.The impact of preoperative micronutrient supplementation in lung surgery.A prospective randomized trial of oral supplementation of combinedalpha-ketoglutaric acid and 5-hydroxymethylfurfural.European journal of cardio-thoracic surgery : officialjournal of the European Association for Cardio-thoracic Sur-gery 32,776-82(2007).
15.Reznick，A. Z. et al. Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation.The Biochemical journal286(Pt 2,607-11(1992).
16.Smith, C. D. et al.Excess brain protein oxidation and enzyme dysfunction in nor-mal aging and in Alzheimer disease. Proceedings of the National Academy of Sci-ences of the United States of America 88,10540-3 (1991).
17.Stadtman,E.R.& Oliver,C.N. metal-catalyzed oxidation of proteins. Physiological consequences.The Journal of biological chemistry 266,2005-8 (1991).
18.Starke-Reed, P. E.& Oliver,C. N. Protein oxidation and proteolysis during aging and oxidative stress.Archives of biochemistry and biophysics 275,559-67 (1989).
19. Wiseman,H.& Halliwell,B. Damage to DNA by reactive oxygen and nitrogen spe-cies: role in inflammatory disease and progression to cancer. The Biochemicaljour-nal 313 ( Pt 1,17-29 (1996).
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