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品牌名称：

型号规格：

批准文号： 仅供科研使用

产品标签：

产品卖点：

销售渠道：医院

025-86978335

产品介绍：

【产品名称】

通用名称：大/小鼠生长因子I检测试剂盒（酶联免疫法）

英文名称：Mouse-/Rat-IGF-I ELISA

【预期用途】

用于小鼠和大鼠血清和血浆中 IGF-I 的测量。仅供科研使用。不用于临床诊断。

【包装规格】

96T/盒

【背景知识】

胰岛素样生长因子 (IGF)-1 和 -II 发挥作用在调节多种细胞类型的增殖、分化和特定功能中起关键作用 (1-3)。IGF-l 与 somatomedin C(Sm-C) (4) 相同，分子量为 7649 道尔顿 (5)。它的主要调节剂是生长激素 (WHi) 和食物。

与许多其他激素不同，IGF 以高亲和力与特异性结合蛋白 (IGFBP) 结合。目前已知有七种不同的结合蛋白 (7,8,22)，它们要么以相似的亲和力结合 IGF-I 和 IGF-II，要么偏好 IGF-II (9,10)。测定 IGF-I 的一个主要问题是测定中对 IGFBP 的干扰。在未处理的血清样品中直接测定 (11) 会导致不正确的结果，因为由于 IGF-I/IGFBP-3 复合物的解离速度极慢，因此在测定孵育期间只有部分 IGF-可用于测量。根据样品中 IGF-/ 与 IGFBP 的比率，会发生干扰。

参考文献：

1. Baxter RC.1986 The somatomedins: insulin-like growth factors.Adv Clin Chem.25:49-115

2. Daughaday WH,Rotwein P.1989 Ilnsulin-like growth factors I and ll. Peptide, messenger ribonucleic acid and gene structures, serum,and tissue concentrations.Rev.10:68-91

3. Spencer EM(Ed.)1991 Modern Concepts of Insulin-Like Growth Factors.New York: Elsevier.

4. Klapper DG,Svoboda ME,Van Wyk JJ.1983 Sequence analysis of somatomedin-C: confimation of identity with insulin.like growthfactor-l. Endocrinology.112:2215-2217.

5. Rinderknecht E, Humbel RE.1978The amino acid sequence of human insulin-like growth factor l and its stuctural homology withproinsulin.J Biol Chem. 253:2769-2276.

6. Clemmons DR,Van Wyk J.1984 Factors controlling blood concentration of somatomedin C. Clin Endocrinol metab.13:113-143.

7. Ballard J,Baxter R,Binoux M, et al.1989 on the nomenclature of the lGF binding proteins. Acta Endocrinol (Copenh).121:751-752.

8. dro SLS.1992Report on the nomenclature of the IGF binding pro-teins. J.Clin Endocrinol metab.74:1215-1216.

9. Martin JL, Baxter RC.1986 Insuln-like growth factor binding protein from human plasma.Purification and characterization.J Biol Chem.261:8754-8760.

10. Binkert C, Landwehr J,Mary.JL. Schwander J. Heinrich G.1989 Cloning.sequence analysis and expression of a cDNA encoding anovel insulin-like growth factor binding protein (IGFBP-2).EMBOJ.8:2497-2502.

11. Furlanetto RW, Underwood LE, Van Wyk JJ, DErcole AJ.1977Estimation of somatomedin-C levels in normals and patients withpituitary disease by radioimmunoassay.J. Clin lnvest.60:648-657.

12. Daughaday WH,KapadiaM,Mariz l.1987 Serum somatomedin binding proteins: physiologic significance and interference in radioligandassay.J Lab Clin Med.109:355-363.

13. Breier BH, Gallaher BW, Gluckman PD.1991Radioimmuncassay for insulin-like growth factor-l: solutions to some potential problemsand pitfalls.J Endocrinol.128:347-357.

14. Daughaday WH,Mariz K, Blethen SL..1980 Inhibion of access of bound somatomedin to membrane receptor and immunobindingsites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanolextracted serum.J Clin

Endocrinol metab.51:781-788.

15. Blum WF, Gallaher B, Ranke MB.1992 AnIGFBP-blocked IGF-IRIA that measures what it pretends to measure:IGF-4.74th AnnualMeeting of the American Endocrine Society. 293.

16. Rosenfeld RG,Wlson DM, Lee PDK, Hintz RL.1986 Insulin-like growth factors l and ll in evaluation of growth retardation.J Pediatr.109:428-433.

17. Clemmons DR, Van-Wyk JJ, Ridgway EC,Kliman B, Kielberg RN. Undewood LE.1979 evaluation of acromegaly byradioimmunoassay of somatomedin-C.N.Engl J Med.301:1138-1142

18. Zapf J, Walter H,Froesch ER. 1981 Radioimmunological detemination of insulin-like growth factors I and ll in nomal subjects and inpatients with growth disorders and extrapancreatic tumor hypoglycemia.J Clin Invest. 68:1321-1330.

19. Blum WF.1992 Insulin-like growth factors and their binding proteins. ln:Ranke MB,ed.FunctonalEnderinolgic Dlagnostics inChildren and Adolescence. Mannheim:J+JVerlag; 102-117.

20. Rieu M,Girard F, Bricaire H, Binoux M.1982 The importance of insulin-like growth factor (somatomedin) measurements in the diagnosisand surveillance of acromegaly.J Clin Endocrinol metab.55:147-153.

21. Blum WF, Ranke MB,Bierich JR.1988 A specific radioimmunoassay for insuln-like growth factor l: the interference of GF bindingproteins can be blocked by excess IGF-I.Acta Endocrinol (Copenh).118:374-380.

22. Wlson EM,Oh Y, Rosenfeld RG(1997)Generation and characterization of an lGFBP-7 antibody.ldentification of 31 kDIGFBP-7 inhuman biological fuids and Hs578T human breast cancer conditioned media.J Clin Endocrinol metab Vol 82,4:1301-1303

23. Ranke MB, Schweizer R, EIminger MW, Weber K, Binder G, Schwarze CP, WolmannHA(2000) Significance of basalIGF-,IGFBP-3and lGFBP-2 measurements in the diagnostics of short stature in children. Horm Res 54:60-68

24. Ranke MB,Schweizer R, EIminger MW, WleberK,Binder G, Schwarze CP, Wollmann HA (2001)Relevance of lGF-4,)IGFBP-3 andIGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents. Horm Res 55:155-124

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