北京荣志海达生物科技有限公司
东方医疗器械网客服中心
025-86978335
所在地区：北京/海淀区
（企业已暂停产品招商，代理采购咨询可以留言）
品牌名称：
型号规格：
批准文号： 仅供科研使用
产品标签：
产品卖点：
销售渠道：诊所
025-86978335
| 器械类别 | 其它 | 科室 | 诊断相关科室 |
| 功能 | 检测试剂盒 | 标准目录 | 体外循环及血液处理设备 |
| 耗材类别 | 诊断试剂 | 其他分类 | 进口 |
| 家用与否 |
产品介绍：
【产品名称】
通用名称：脂联素检测试剂盒（酶联免疫法）
英文名称：Adiponectin ELISA
【预期用途】
用于定量测量人血清或血浆中人脂联素。仅供科研使用。不用于临床诊断。
【包装规格】
96T/盒
【背景知识】
脂联素是一种30 kDa的蛋白质，在血清中以高浓度（0.01%）存在，该蛋白质主要由脂肪细胞合成，但肌肉细胞和肝细胞也能合成脂联素。它由一个胶原样 N 端和一个球状 C 端结构域组成 [1]。在体内，脂联素存在于不同的寡聚体中。除三聚体和二三聚体外，还存在高分子多聚体[1-3]。已知有两种不同的受体，两种受体都普遍表达，但在组织中的分布不同。脂联素受体 1 (AdipoR1) 特别在肌肉中合成，而 AdipoR2 特别在肝组织中合成 [4]。
研究表明，脂联素与 BMI 呈负相关，因此可能对能量代谢很重要，例如通过调节脂肪酸氧化与 ll 型糖尿病的联系。脂联素也代表了葡萄糖和脂肪代谢之间的联系 [8, 9]。
不同描述的高分子多聚体的特殊诊断价值无法在三种商业测试系统的比较研究中得到证明 [10]。使用 ROC 分析，Blüher 等人能够确定诊断胰岛素抵抗的“曲线下面积”为 0.92。这表明使用 Mediagnost E09 [10] 测量脂联素可能具有诊断益处。
此外，脂联素参与炎症过程 [11-15]，因此对于动脉硬化 [4, 5, 16] 和冠状动脉炎症 [17, 18] 的发展很重要，以估计冠状动脉疾病 [19,20]。脂联素还影响其他生理过程，例如血管生成 [21,22]。
参考文献：
1. Nakano, Y., et al., Isolation and characterization of GBP28, a novel gelatin-bindingprotein purified from human plasma.J Biochem (Tokyo),1996.120(4): p.803-12.
2. Pajvani, U.B., et al., Structure-function studies of the adipocyte-secreted hormoneAcrp30/adiponectin. lmplications fpr metabolic regulation and bioactivity.J Biol Chem, 2003.278(11): p.9073-85.
3. Tsao, T.S., et al.,Role of disulfide bonds in Acrp30ladiponectin structure and signalingspecificity. Different oligomers activate different signal transduction pathways. J Biol Chem,2003.278(50): p.50810-7.
4. Shimada,K.,T. Miyazaki, and H.Daida,Adiponectin and atherosclerotic disease.ClinChim Acta, 2004.344(1-2): p.1-12.
5. Higashiura, K., et al., Correlations of adiponectin level with insulin resistance andatherosclerosis in Japanese male populations. Clin Endocrinol (Oxf), 2004.61(6): p.753-9.6.Spranger, J., et al., Adiponectin is independently associated with insulin sensitivity inwomen with polycystic ovary syndrome.Clin Endocrinol (Oxf),2004.61(6): p.738-46.
7. Zoico, E., et al., Adipocytokines, fat distribution, and insulin resistance in elderly menand women.J Gerontol A Biol Sci Med Sci,2004.59(9): p.M935-9.
8. Ye,J.M., et al.,PPARalpha lgamma ragaglitazar eliminates fatty liver and enhancesinsulin action in fat-fed rats in the absence of hepatomegaly.Am J Physiol Endocrinol metab,2003.284(3): p.E531-40.
9. Yamauchi, T., et al., Adiponectin stimulates glucose utilization and fatty-acid oxidationby activating AMP-activated protein kinase.Nat Med, 2002.8(11): p. 1288-95.
10. Blüher(Blueher), M., et al.,Total and high-molecular weight adiponectin in relation tometabolic variables at baseline and in response to an exercise treatment program:
comparative evaluation of three assays. Diabetes Care, 2007.30(2): p. 280-5.
11.Delaigle,A.M., et al., Induction of adiponectin in skeletal muscle by inflammatorycytokines: in vivo and in vitro studies.Endocrinology, 2004.145(12): p. 5589-97.
12. Winzer, C., et al.,Plasma adiponectin, insulin sensitivity, and subclinical inflammationin women with prior gestational diabetes mellitus. Diabetes Care, 2004.27(7): p. 1721-7.13. Xydakis,A.M., et al., Adiponectin, inflammation, and the expression of the metabolicsyndrome in obese individuals: the impact of rapid weight loss through caloric restriction.JClin Endocrinol metab, 2004.89(6): p. 2697-703.
14. Motoshima, H., et al.,Adiponectin suppresses proliferation and superoxide generationand enhances eNOS activity in endothelial cells treated with oxidized LDiL. Biochem BiophysRes Commun,2004.315(2): p.264-71.
15. Wolf,A.M., et al.,Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes.Biochem Biophys Res Commun, 2004.323(2): p.630-5.
16. Okamoto, Y., et al., Adiponectin reduces atherosclerosis in apolipoprotein E-deficientmice. Circulation,2002.106(22): p.2767-70.
17. Schlegel,A., Adiponectin and risk of coronary heart disease.Jama,2004.292(1): p.40; author reply 40.
18. Choi, K.M., et al., Inflammation, Insulin Resistance, and Glucose Intolerance in AcuteMyocardial Infarction Patients without a Previous Diagnosis of Diabetes Mellitus.J Clin
Endocrinol metab,2004.
19. Nakamura,Y.,et al., lmplications of plasma concentrations of adiponectin in patientswith coronary artery disease.Heart, 2004.90(5): p.528-33.
20. Pischon, T., et al., Plasma adiponectin levels and risk of myocardial infarction in men.Jama,2004.291(14): p.1730-7.
21.Shibata, R., et al.,Adiponectin stimulates angiogenesis in response to tissue ischemiathrough stimulation of amp-activated protein kinase signaling.J Biol Chem, 2004.279(27): p.28670-4.
22. Fernandez-Real, J.M., et al.,Adiponectin is associated with vascular functionindependent of insulin sensitivity. Diabetes Care, 2004.27(3): p.739-45.
